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Editor: ovcharenko
Categories
Name: Dmitriy Ovcharenko Email: Send to ovcharenko Home Page: http://ovcharenko-nsk.com ovcharenko's bookmarks (5) Photo:
Health: Conditions and Diseases: Cancer: Hematologic (256)
Health: Medicine: Medical Specialties: Hematology (127)
Science: Biology: Biochemistry and Molecular Biology: Gene Expression: RNA Interference (85)
Science: Biology: Products and Services (375)
Science: Biology: Products and Services: General Distributors (89)
Profile
My main research interest is microRNA (miRNA) therapeutics. MiRNAs are small RNA molecules encoded in the genomes of plants and animals that regulate the expression of genes by binding to the 3'-untranslated regions of specific mRNAs. MicroRNA is involved in the RNA interference (RNAi) mechanism and play a critical role in gene silencing. Misregulation of miRNA expression was found in several diseases including cancer. Application of microRNAs as therapeutic targets represent a novel molecular based approach for developing new medicines.PUBLICATIONS
Ovcharenko et al. Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway. Cancer Research 67: 10782-10788 (2007) PubMed link
Johnson et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Research 67: 7713-7722 (2007) PubMed link
Ovcharenko et al. High-throughput RNAi screening in vitro: From cell lines to primary cells. RNA 11: 985-993 (2005) PubMed link
Ovcharenko et al. Mir-10a overexpression is linked to a HOX gene cluster in intermediate risk acute myeloid leukemia (AML) patients with NPM1 mutations. In Print.
Sachse et al. High throughput RNAi strategies for target discovery and validation by using synthetic siRNAs: functional genomics investigations of biological pathways. Methods in Enzymology 392: 242-277 (2005) PubMed link
Tong et al. Neutrophil gelatinase associated lipocalin as a survival factor. Biochemical Journal 391: 441-448 (2005) PubMed link
Loots et al. Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Research 15: 928-935 (2005) PubMed link
Sirotkin et al. Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen. Journal of Cellular Physiology. In Print.
Boffelli et al. Phylogenetic Shadowing of Primate Sequences to Find Functional Regions of the Human Genome. Science 299: 1391-1394 (2003) PubMed link
Patent: Methods and compositions involving miRNA and miRNA inhibitor molecules. USA patent numbers: 20080171715, 20080050744, 20080176766.
Patent: System and method for electroporating a sample. USA patent number #6,897,069. Issue date: May 24, 2005.
Patent: System and method for electroporating a sample. USA patent number #7,393,681. Issue date: July 1, 2008.
Dmitriy Ovcharenko, Thomas Illmer, Jeffrey Shelton, Emmanuel Labourier, David Brown. Expression profiling and functional studies reveal a potential role for microRNAs in human acute myeloid leukemia. The American Society of Cell Biology, San Francisco, CA (2005).
Dmitriy Ovcharenko, Kevin Kelnar, Angie Cheng, David Wang, Lance Ford. The use of miRNA and siRNA libraries to identify genes involved in the regulation of hTERT transcription. The American Society of Cell Biology, San Francisco, CA (2005).
Richard Jarvis, Mike Byrom, Dmitriy Ovcharenko, Christina Buchanan, David Brown. SiRNA libraries as tools for target identification. The American Society of Cell Biology, San Francisco, CA (2005).
Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. Experimental Biology (FASEB),San Diego, CA (2005).
Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. AACR 96th Annual Meeting, RNA Interference, Small Interfering RNAs, and MicroRNAs: From Mechanism to Cancer Therapeutics, Anaheim, CA (2005).
Dmitriy Ovcharenko, Richard Jarvis. High Throughput In Vitro RNAi Screening: From Cell Lines To Primary Cells. Twelfth International Symposium on Recent Advances in Drug Delivery Systems (2005).
Dmitriy Ovcharenko, Kevin Kelnar, Richard Jarvis. Efficient Delivery of siRNA to Primary Cells and Hard-to-Transfect Cell lines. Gene Delivery 3rd Annual International Conference (2003).
Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. AACR 96th Annual Meeting, Cellular and Molecular Biology Symposium, Anaheim, CA (2005).
Dmitriy Ovcharenko, Richard Jarvis. High Throughput In Vitro RNAi Screening: From Cell Lines To Primary Cells. Twelfth International Symposium on Recent Advances in Drug Delivery Systems (2005).
Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. AACR 96th Annual Meeting, Cellular and Molecular Biology Symposium, Anaheim, CA (2005).
Dmitriy Ovcharenko, Richard Jarvis. High Throughput In Vitro RNAi Screening: From Cell Lines To Primary Cells. Twelfth International Symposium on Recent Advances in Drug Delivery Systems (2005).
Ovcharenko D. et al. Effective delivery of functional siRNAs into cells. Pharmaceutical Discovery, Current Applications in RNAi, p.21-26 (2005)
Ovcharenko D. et al. High throughput siRNA delivery in vitro: From cell lines to primary cells. Ambion TechNotes 12,(2): p.11-13 (2005)
Ovcharenko D. et al. High throughput siRNA electroporation. Ambion TechNotes 12,(1):p.14-15 (2005)
Ovcharenko D. et al. Deliver siRNAs into primary cells. Ambion TechNotes 12,(1):p.16-17 (2005)
Brown D. et al. Precursor miRNAs for successful miRNA functional studies. Ambion TechNotes 12,(1):p. 3-5 (2005)
Beauchamp L. et al. Got small RNA? Ambion TechNotes 12,(1):p.6-7 (2005)
Ovcharenko D. et al. Delivering siRNAs to difficult cell types. Ambion TechNotes 11,(3):p. 14-15 (2004)
Ovcharenko D. et al. Efficient delivery of siRNAs to human primary cells. Ambion TechNotes 10,(5):p.15-16 (2003)
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