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Editor:  ovcharenko

Name:	Dmitriy Ovcharenko
Email:	Send to ovcharenko
Home Page:	http://ovcharenko-nsk.com
	ovcharenko's bookmarks (5)
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Health: Conditions and Diseases: Cancer: Hematologic  (275)
Health: Medicine: Medical Specialties: Hematology  (135)
Science: Biology: Biochemistry and Molecular Biology: Gene Expression: RNA Interference  (74)
Science: Biology: Products and Services: General Distributors  (74)

Profile

My main research interest is microRNA (miRNA) therapeutics. MiRNAs are small RNA molecules encoded in the genomes of plants and animals that regulate the expression of genes by binding to the 3'-untranslated regions of specific mRNAs. MicroRNA is involved in the RNA interference (RNAi) mechanism and play a critical role in gene silencing. Misregulation of miRNA expression was found in several diseases including cancer. Application of microRNAs as therapeutic targets represent a novel molecular based approach for developing new medicines.

PUBLICATIONS

Ovcharenko et al. Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway. Cancer Research 67: 10782-10788 (2007) PubMed link

Johnson et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Research 67: 7713-7722 (2007) PubMed link

Ovcharenko et al. High-throughput RNAi screening in vitro: From cell lines to primary cells. RNA 11: 985-993 (2005) PubMed link

Sachse et al. High throughput RNAi strategies for target discovery and validation by using synthetic siRNAs: functional genomics investigations of biological pathways. Methods in Enzymology 392: 242-277 (2005) PubMed link

Tong et al. Neutrophil gelatinase associated lipocalin as a survival factor. Biochemical Journal 391: 441-448 (2005) PubMed link

Loots et al. Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Research 15: 928-935 (2005) PubMed link

Boffelli et al. Phylogenetic Shadowing of Primate Sequences to Find Functional Regions of the Human Genome. Science 299: 1391-1394 (2003) PubMed link

PATENTS

System and method for electroporating a sample. USA patent number #6,897,069 (2005)

PRESENTATIONS

1. Dmitriy Ovcharenko, Kevin Kelnar, Tim Davidson, Jeffrey Shelton, David Kosel, David Brown, Thomas Illmer. Role of microRNAs in human acute myeloid leukemia (AML) samples with different cytogenetic risk profiles. American Association for Cancer Research 2007 Annual Meeting, Los Angeles, CA (2007)

2. Dmitriy Ovcharenko. MicroRNA for cancer therapeutics. Molecular Therapeutics of Cancer, Gordon Research Conferences, New London, NH (2007)

3. MicroRNAs as biomarkers in human solid tissues, blood, and other biofluids. National Cancer Institute, Specialized Programs of Research Excellence, Baltimore, MD (2007)

4. Dmitriy Ovcharenko, Thomas Illmer, Jeffrey Shelton, Emmanuel Labourier, David Brown. Expression profiling and functional studies reveal a potential role for microRNAs in human acute myeloid leukemia. The American Society of Cell Biology, San Francisco, CA (2005)

5. Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. AACR 96th Annual Meeting, Cellular and Molecular Biology Symposium, Anaheim, CA (2005)

6. Dmitriy Ovcharenko, Richard Jarvis. High Throughput In Vitro RNAi Screening: From Cell Lines To Primary Cells. Twelfth International Symposium on Recent Advances in Drug Delivery Systems (2005)

7. Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. Experimental Biology (FASEB), San Diego, CA (2005)

INDUSTRY PUBLICATIONS

Ovcharenko D. et al. Effective delivery of functional siRNAs into cells. Pharmaceutical Discovery, Current Applications in RNAi, p.21-26 (2005)

Ovcharenko D. et al. High throughput siRNA delivery in vitro: From cell lines to primary cells. Ambion TechNotes 12,(2): p.11-13 (2005)

Ovcharenko D. et al. High throughput siRNA electroporation. Ambion TechNotes 12,(1):p.14-15 (2005)

Ovcharenko D. et al. Deliver siRNAs into primary cells. Ambion TechNotes 12,(1):p.16-17 (2005)

Brown D. et al. Precursor miRNAs for successful miRNA functional studies. Ambion TechNotes 12,(1):p. 3-5 (2005)

Beauchamp L. et al. Got small RNA? Ambion TechNotes 12,(1):p.6-7 (2005)

Ovcharenko D. et al. Delivering siRNAs to difficult cell types. Ambion TechNotes 11,(3):p. 14-15 (2004)

Ovcharenko D. et al. Efficient delivery of siRNAs to human primary cells. Ambion TechNotes 10,(5):p.15-16 (2003)

WEBSITE

www.ovcharenko-nsk.com

microRNA and Cancer Therapeutics